Principal Scientist, ADME-PK jobs in United States
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Dyne Therapeutics · 5 hours ago

Principal Scientist, ADME-PK

positionWaltham, MA
timeFull-time
remoteOnsite
senioritySenior Level, Lead/Staff
money$159K/yr - $195K/yr
date6+ years exp

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. The Principal Scientist, ADME-PK will utilize their expertise in drug metabolism and pharmacokinetics to advance the company's therapeutic efforts targeting muscle and CNS tissues.

BiotechnologyHealth CareMedicalPharmaceutical
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Growth Opportunities
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H1B Sponsor Likelynote

Responsibilities

Design and execute internal/external preclinical studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of Dyne's drug candidates
Represent PCD as the ADME-PK subject matter expert on discovery and program teams
Partner with and support Research, Toxicology, Translational Biomarkers, Clinical, Regulatory, Project Management and other Dyne departments
Collaborate with Clinical Pharmacology/Pharmacometrics to develop quantitative tools to translate PK/PD relationship from preclinical to clinical
Author high quality Regulatory documents including INDs, CTAs, and NDA/BLA filings
Prepare strategic and science-based ADME strategies that meet regulatory requirements and program goals
Facilitate strategic scientific communication via meetings, abstracts and manuscripts

Qualification

PharmacokineticsADME conceptsDrug metabolismBioanalytical principlesWinNonlin softwarePK characterizationCommunicationInterpersonal skillsPresentation skillsTeam collaboration

Required

PhD in Pharmacokinetics, Pharmacology, Pharmaceutics, Biomedical Sciences or other relevant field with >6 years (MS with >8 years, BS with >12 years) of experience in the biopharmaceutical industry, with evidence of drug development experience
Strong knowledge of drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamics and bioanalytical principles
Proficient in using WinNonlin or other pharmacokinetic software
Excellent communication (verbal and written) and presentation skills, as well as interpersonal skills and the ability to represent PCD in a team environment

Preferred

Familiarity with regulatory submission including FIH dosing strategy is highly desirable
Experience with PK characterization of protein therapeutics or antibody-drug conjugates (ADCs) is desired

Company

Dyne Therapeutics

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Dyne Therapeutics is a developer of targeted therapies intended for serious muscle diseases.
dateFounded in 2018
location
Cambridge, Massachusetts, USA
people-size51-200 employees
web-link
https://www.dyne-tx.com/

H1B Sponsorship

Dyne Therapeutics has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (4)
2024 (7)
2023 (1)
2022 (3)
2021 (6)

Funding

Current Stage
Public Company
Total Funding
$1.67B
Key Investors
Hercules CapitalAtlas Venture
2025-12-09Post Ipo Equity· $402.5M
2025-06-30Post Ipo Equity· $230M
2025-06-30Post Ipo Debt· $100M

Leadership Team

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John Cox
Chief Executive Officer
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Recent News

GlobeNewswire
Dyne Therapeutics Appoints Vikram Karnani to Board of Directors
2025-12-24
MarketScreener
Dyne Therapeutics, Inc. Announces the Appointment of Vikram Karnani to Its Board of Directors
2025-12-24
thefly.com
Dyne Therapeutics appoints Vikram Karnani to board of directors
2025-12-24
Company data provided by crunchbase