Nautilus Biotechnology · 2 hours ago
Principal Software Engineer
United States
Full-time
Remote
Lead/Staff
$224K/yr - $337K/yr
10+ years expNautilus Biotechnology is dedicated to improving health by advancing drug development through innovative protein analysis technologies. The Principal Software Engineer will lead the design and development of a cloud-based protein identification pipeline while providing technical leadership and mentorship to the engineering team.
BiotechnologyHealth CareLife SciencePharmaceutical
Responsibilities
You will own and deliver a major portion of our production protein identification pipeline and internal data management systems, including design, estimation and scheduling, development, deployment, and operationalization
You are comfortable moving between layers of the stack, from high-performance C++ code to web presentation layers and everything in between
You will work closely and cross-functionally with representatives of other disciplines, including bioinformatics, biology, and engineering, to deeply understand their workflows and problems – whether open-ended or well-defined – and solve them
You will remain current on new technologies and available vendor packages; evaluate them and make recommendations as necessary
You will mentor Software Engineers and Bioinformaticists to assist with skill/knowledge development through advice, coaching, and training opportunities
You will determine and implement software engineering process improvements and best practices
Qualification
Required
A minimum of 10+ years of relevant experience in a high performing software engineering organization(s) is required
Bachelor's degree in Computer Science or similar related field is required
You must have a strong, analytical background with the ability to translate complex algorithms into high performance software
You must have an excellent track record of delivering complex software systems on-time and with high quality
You must have fluency in a variety of programming concepts, languages, and tools – we are currently invested in Python, with C++ for time-critical tasks
You must understand the fundamentals of modern cloud-based architectures – we are currently invested in AWS Batch, Step Functions, Lambdas, and related technologies
You work well in teams, and have a track record of making your teams better
You have fun when building complex systems while working side-by-side with experts from a variety of disciplines
Company
Nautilus Biotechnology
Nautilus Biotechnology offers a high-throughput, low-cost platform for analyzing and quantifying the human proteome.
51-200 employees
H1B Sponsorship
Nautilus Biotechnology has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (3)
2023 (2)
2022 (6)
2021 (1)
2020 (2)
Funding
Current Stage
Public CompanyTotal Funding
$303.2MKey Investors
Perceptive AdvisorsVulcan Capital
2021-06-10Post Ipo Equity· $200M
2021-06-09IPO
2020-05-21Series B· $76M
Leadership Team
Mary Godwin
Sr. Vice President, Operations, Nautilus Biotechnology
Martin Huber
VP of Biochemistry and Flow Cell Development
Recent News
Nautilus Biotechnology Inc.
2025-12-24
2025-12-02
Longevity.Technology - Latest News, Opinions, Analysis and Research
2025-11-04
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