Prime Medicine, Inc. · 4 days ago
Scientist I, Cell-Based Assays
Cambridge, MA
Full-time
Onsite
New Grad, Entry, Mid Level
$120K/yr - $147K/yr
0+ years expPrime Medicine is a leading biotechnology company focused on gene editing therapies. The Scientist I role involves leading assessments of in vitro and in vivo delivery to lung epithelial cells, utilizing various cell culture methods and collaborating with internal teams on research projects.
BiotechnologyGeneticsLife ScienceMedicalTherapeutics
Responsibilities
Utilize 2D and 3D epithelial cell cultures to assess delivery and potency of AAV- and LNP-based discovery candidates
Differentiating and maintaining multiple primary epithelial cell cultures
Preparing/dissociating cells and tissues into single cell suspensions to perform cell-based analyses using flow cytometry and molecular biology techniques
Collaborate cross-functionally with internal teams on study design, execution, data collection, data analysis, and interpretation
Present data in written reports and oral presentations
Qualification
Required
PhD in cell biology, immunology, genetics, developmental biology, or related field with 0-2+ years of relevant experience (or BS+8, MS+6)
Experience with complex non-immune primary mammalian cell cultures, including cell differentiation and use of transwells
Experience dissociating tissues for downstream cell-based assays
Familiarity/experience with molecular biology techniques (e.g., qPCR, DNA sequencing, western blot)
Strong organizational and critical thinking skills, attention to detail, and ability to work both independently and as part of a collaborative team
Excellent communication and interpersonal skills to thrive in a cross-functional setting
Preferred
Subject matter expertise in lung biology, drug development for lung diseases, and considerations for in vivo delivery of test articles to the lung
Hands-on experience with in vivo lung delivery (intratracheal and nebulization)
Hands-on experience with flow cytometry panel design, sample preparation, instrument operation, and data analysis
Experience with cell sorting
Development of cell-based immunogenicity assessments such as intracellular cytokine staining and ELISPOT
Benefits
Robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs
Generous paid time off
Wellness days
Company-wide recharge breaks
Company
Prime Medicine, Inc.
Prime Medicine was founded to bring the promise of gene editing to patients.
201-500 employees
H1B Sponsorship
Prime Medicine, Inc. has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (7)
2024 (12)
2023 (11)
2022 (5)
2021 (5)
Funding
Current Stage
Public CompanyTotal Funding
$558.15MKey Investors
Google VenturesCystic Fibrosis FoundationBristol-Myers Squibb
2025-08-01Post Ipo Equity· $4.95M
2025-07-30Post Ipo Equity· $144.2M
2025-07-16Post Ipo Equity· $24M
Leadership Team
Allan Reine
Chief Executive Officer and Board Member
Andrew Anzalone
Director, Head of Prime Editing Platform
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