Guardant Health · 1 month ago
Staff HPC Infrastructure Engineer
Palo Alto, CA
Full-time
Hybrid
Senior Level, Lead/Staff
$175K/yr - $236K/yr
4+ years expGuardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. The Staff HPC Infrastructure Engineer will act as a technical lead in day-to-day operations, manage HPC interconnects, and integrate various systems to enhance the computational infrastructure.
BiotechnologyHealth CareHealth DiagnosticsOncologyTherapeutics
Responsibilities
Act as a technical lead in day to day operations
Help manage the HPC interconnects
Help integrate the HPC systems with the bandwidth on-demand system
Help integrate the HPC system with the single namespace storage system
Help integrate cloud bursting as part of the HPC abstraction work
Work with the networking infrastructure team to manage and optimize the connectivity to and from the HPC systems and locales
Help manage multiple HPC clusters and cluster file systems
Help research, develop and implement the next generation HPC solution
Troubleshoot the production system stack down to source code level e.g. shell scripts, python and others
Maintain, monitor, and support the infrastructure environment and/or facilities
Use and maintain enhanced production monitoring and additional capability
Support improvements for increased system reliability and performance
Support multiple systems or applications of medium to high complex (complexity defined by size, technology used, and system feeds and interfaces) with multiple concurrent users, ensuring control, integrity, and accessibility
Support systems at remote locations, including internationally
Work with offsite consultants to maintain the infrastructure
Work with vendors to troubleshoot, upgrade and repair systems as needed
Participate in a 24/7 on-call rotation
Qualification
Required
B.S. in Computer Science or related field
4+ years of TCP/IP networking experience
2+ years of RDMA networking experience
4+ years of Linux/Unix administration, knowledge of Unix network protocols, TCP/IP network fundamentals, core infrastructure technologies and virtualization
2+ years of large-scale data storage and compute clusters (HPC) infrastructure
2+ years working in and with on-premise and cloud-based (AWS, Google, IBM and Azure) data-centers
2+ years of building software release and ops processes and automation toolset
2+ years providing documentation of system administration
Preferred
Cisco Certified Network Professional certification
Experience with Arista and compatible networking, up to and including 400 gb/s links
Experience with Mellanox infiniband fabric
Experience administering IBM's General Parallel File System
Experience administering SLURM scheduler
Experience with using warewulf
Experience with cloud bursting technologies
Experience with wide area file systems
Experience with docker and container technologies
Experience with Kubernetes
Operating infrastructure compliant with HIPAA and SOX standards
Company
Guardant Health
Guardant Health is a precision oncology company that uses blood tests, data sets, and analytics to provide treatment to cancer patients.
1001-5000 employees
H1B Sponsorship
Guardant Health has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (38)
2024 (50)
2023 (40)
2022 (72)
2021 (57)
2020 (29)
Funding
Current Stage
Public CompanyTotal Funding
$2.53BKey Investors
Baillie GiffordSoftBank Vision FundOrbiMed
2025-11-05Post Ipo Equity· $284.4M
2025-11-05Post Ipo Debt· $350M
2023-12-21Post Ipo Equity· $90.7M
Leadership Team
AmirAli Talasaz
Co-founder and Co-Chief Executive Officer
Helmy Eltoukhy
Chairman and Co-Chief Executive Officer
Recent News
2026-01-12
Company data provided by crunchbase