NextGen Tides · 1 month ago
Synthesis Scientist
San Diego, CA
Full-time
Onsite
Mid, Senior Level
0+ years expNextGen Tides is a fast-growing biotech startup focused on oligonucleotide and conjugation technologies. They are seeking a Scientist or Senior Scientist to join their core chemistry team, where the role involves executing high-quality synthesis and purification while optimizing methods for client projects and internal R&D.
Biotechnology
Responsibilities
Oligo Synthesis: Write protocols and perform solid-phase synthesis of DNA, RNA, ASO, siRNA, PMO, and modified oligos
Analysis & QC: Operate and interpret data using LC–MS (Waters) and HPLC (Agilent) to ensure purity and identity
Instrument Management: Maintain and troubleshoot automated oligo synthesizers ( Mermade / Dr. Oligo )
Purification: Execute purification and deprotection workflows with a focus on high quality and yield
Innovation: Support peptide–oligo conjugates and AOC-related chemistries, contributing to overall platform development
Optimization: Develop and refine synthesis and purification methods to improve efficiency for internal programs
Lab Operations: Maintain lab excellence, including instrument upkeep, documentation, and QC standards
Qualification
Required
PhD in Chemistry, Chemical Biology, or a related field (0–5+ years experience) OR MS/BS with strong, hands-on industry experience
Deep experience with oligonucleotide solid-phase synthesis and automated synthesizers
Strong proficiency in LC–MS, HPLC, and oligo purification workflows
Familiarity with modified backbones (PS, PO) and nucleoside chemistry
A 'startup mindset'—you are independent, organized, a clear communicator, and a proactive problem solver
Preferred
Experience with conjugation chemistries (peptides, lipids, ligands)
Experience building protocols from scratch in a startup environment
Benefits
Healthcare insurance
Paid Time Off (PTO)
Company
NextGen Tides
2-10 employees
Funding
Current Stage
Early StageCompany data provided by crunchbase