Denali Therapeutics · 1 day ago
Director of Toxicology
South San Francisco, CA
Full-time
Onsite
Director/Executive
$204K/yr - $259K/yr
15+ years expDenali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases. The Director of Toxicology will support the nonclinical safety assessment of therapeutics, conducting toxicology studies and collaborating with cross-functional teams to advance drug candidates.
BiotechnologyGeneticsHealth DiagnosticsTherapeutics
Responsibilities
Design and implement nonclinical toxicology programs and strategies to evaluate the safety of Denali's therapeutic candidates
Conduct and oversee non-GLP and GLP toxicology studies, ensuring adherence to regulatory standards
Analyze, interpret, and summarize toxicology data to support safety evaluations
Prepare and present safety data to internal project teams and senior management, contributing to informed decision-making
Assist in the preparation and authoring of regulatory documents related to nonclinical safety assessments
Ensure compliance with relevant regulatory guidelines and standards throughout all stages of toxicology studies
Work closely with colleagues in Research and Development, providing toxicology expertise to support cross-functional project teams
Participate in project meetings, offering insights and recommendations to advance safety assessment strategies
Support investigative efforts into mechanisms of toxicity and contribute to the development of safer therapeutic candidates
Assist in developing and implementing de-risking strategies for drug discovery and development projects
Qualification
Required
PhD in Toxicology, Biology, Pharmacology or related scientific discipline
15+ years of biotech/pharmaceutical drug discovery/development experience
Strong scientific background and scientific aptitude
Excellent critical thinking and scientific skills
Ability to work effectively and collaboratively on cross-functional projects teams, and demonstrated can-do attitude
Ability to work in a fast-paced environment
Excellent oral, presentation, and written communication skills
Preferred
Experience with biologics and oligonucleotides preferred
Benefits
401k
Healthcare coverage
ESPP
A broad range of other benefits
Company
Denali Therapeutics
Denali Therapeutics is dedicated to defeating neurodegenerative diseases to deliver safe and effective medicines to patients and families.
501-1000 employees
H1B Sponsorship
Denali Therapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (11)
2024 (14)
2023 (7)
2022 (6)
2021 (5)
2020 (1)
Funding
Current Stage
Public CompanyTotal Funding
$1.32BKey Investors
Royalty PharmaBaillie Gifford
2025-12-04Post Ipo Debt· $200M
2024-02-27Post Ipo Equity· $500M
2022-10-19Post Ipo Equity· $275M
Leadership Team
Ryan Watts
CEO
Peter Chin
Sr. Vice President & Head of Late-Stage Clinical Development and Medical Affairs
Recent News
Longevity.Technology
2026-01-03
Company data provided by crunchbase