Eli Lilly and Company · 3 days ago
Advisor/Senior Advisor Linker-Payload, Antibody-Drug Conjugate and Bioconjugation Engineering
Indianapolis, IN
Full-time
Onsite
New Grad, Entry, Mid, Senior Level
$129K/yr - $209K/yr
0+ years expEli Lilly and Company is a global healthcare leader headquartered in Indianapolis, Indiana, focused on discovering and delivering life-changing medicines. The Advisor/Senior Advisor will work on bioconjugation chemistry and engineering challenges for Antibody-Drug Conjugates and collaborate with cross-functional teams to develop small molecule chemistry and unit operations for linker-payload synthesis.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Work in a team environment to drive and manage L-P, bioconjugation development in-house and at third-party partners for assigned portfolio assets and capability projects including collaboration with external academic researchers
Partner with colleagues in process development and analytical sciences to develop integrated process solutions that achieve quality by design and data driven decisions with robust control strategies
Be on the ground floor to contribute to developing the future engineering strategy to support clinical stage L-P and bioconjugation and enable registration stage
Create clearly organized development workplans, experimental procedures, data requirements and summaries
Author technical reports and CMC related documents including sections in regulatory submission documents (e.g., IND, IMPD, BLA)
Publish original research externally, travel to conferences to share and learn about the external environment and latest trends and technologies, leveraging those learnings on novel Lilly medicines
Design and execute laboratory experimentation in support of L-P and ADC process design using manual and automated high and low throughput reactors and leverage models to support process development
Utilize engineering and physico-chemical fundamentals towards process design: understanding of heat and mass transfer, thermodynamics, crystallization kinetics, solid-liquid and liquid-liquid separations, drying, lyophilization, experimental design and mixing theory for rapid and robust scale-up
Qualification
Required
PhD in Chemical Engineering, Physical Chemistry, Chemistry, Biochemistry or related field
0-5 years of experience in the pharmaceutical or biotech industry in developing Drug substance (small molecule or biologics) manufacturing process technologies
Preferred
Demonstrable ability to work proactively, independently, collaboratively and tenaciously in an interdisciplinary, dynamic fast paced environment
Experience with antibody-drug conjugate (ADC) modalities is a plus
Experience with novel conjugation chemistries, including but not limited to native cysteine/lysine conjugation, enzymatic, site-specific, and engineered cysteine conjugations is a plus
Experience with running well design experiments, collecting required analytical data, modeling, and scale-up of relevant manufacturing process technologies and unit operations
Advanced computer skills (e.g. computational modeling, coding, data analysis techniques such as multivariate data analysis, machine learning, statistical DoE) are highly desired
Experience with hardware / software automation of processes and data workup and analysis to streamline and speed up experimental and modeling workflows is a plus
Experience with online and offline analytical techniques and PAT such as HPLC, GC, NMR, IR, Raman, and solid state characterization techniques such as XRPD, DSC, TGA, particle size and microscopy to guide isolation process development
Benefits
Company bonus
Company-sponsored 401(k)
Pension
Vacation benefits
Eligibility for medical, dental, vision and prescription drug benefits
Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
Life insurance and death benefits
Certain time off and leave of absence benefits
Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
Company
Eli Lilly and Company
We're a medicine company turning science into healing to make life better for people around the world.
10001+ employees
H1B Sponsorship
Eli Lilly and Company has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
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Trends of Total Sponsorships
2025 (514)
2024 (236)
2023 (167)
2022 (133)
2021 (57)
2020 (52)
Funding
Current Stage
Public CompanyTotal Funding
$6.5M2024-02-12Post Ipo Debt· $6.5M
1978-01-13IPO
Leadership Team
David Ricks
Chair, CEO
Lucas Montarce
Executive Vice President and Chief Financial Officer
Recent News
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2026-01-19
Pharmaceutical Technology
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