Spear Bio · 19 hours ago
Scientist/Senior Scientist, Assay Development.
Woburn, MA
Full-time
Onsite
Mid, Senior Level
$115K/yr - $115K/yr
3+ years expSpear Bio is a rapidly growing biotech start-up dedicated to revolutionizing early disease diagnosis and monitoring. The Scientist/Senior Scientist will advance assay development initiatives for ultrasensitive immunoassays, collaborating closely with various teams and mentoring junior scientists.
BiotechnologyHealth CareHealth Diagnostics
Responsibilities
Develop a portfolio of ultrasensitive, ELISA-based immunoassays throughout the product lifecycle from screening and optimization, to feasibility and verification; this includes planning, design, and execution of benchwork involving antibody selection, conjugation of reagents, buffer optimization, and assay validation of sample matrices for research and clinical use
Conduct scientific research on immunoassay design and troubleshooting techniques including dynamic range, limit of detection, spike and recovery, precision, accuracy, and assay linearity; employ DOE and data analysis methodologies to meet project timelines
Organize, document, and review reports for assay development process in preparation for product launches
Collaborate with cross-functional teams to generate marketing materials, internal reports, conference posters, and presentations utilizing immunoassay development data results
Mentor junior scientists and provide guidance on projects
Qualification
Required
Ph.D. plus 1-3+ years or MS plus 4-5+ years of life sciences industry experience designing, developing, and troubleshooting ultrasensitive, blood-based immunoassays for neurodegenerative biomarkers
Deep subject matter expertise in ultrasensitive, immunoassay development including: assay planning, optimization, and troubleshooting with specific focus on antibody screening and conjugation, preanalytical serum, plasma, or EV sample preparation and evaluation, assay diluent formulation, and homogenization for multiplexing
Demonstrated experience utilizing literature to remain at the forefront of research for neurodegenerative protein biomarkers and diseases, and applying the latest research insights to generate immunoassays for clinical application
Advanced understanding and experience with ligand binding assays and diverse analytical and ultrasensitive platforms (e.g. Simoa, MSD, Lumipulse, NULISA)
Experience with FDA and CLSI guidelines to design and execute feasibility and verification testing for developed assays
Can work 5 days/week on site in Woburn, MA
Benefits
Competitive compensation
Meaningful stock ownership
Comprehensive benefits
Great work environment
Company
Spear Bio
Spear Bio is a biotech company that focuses on the detection of ultrasensitive protein.
11-50 employees
H1B Sponsorship
Spear Bio has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (2)
2024 (2)
2023 (3)
2022 (2)
2021 (1)
Funding
Current Stage
Early StageTotal Funding
$45M2024-07-29Series A· $45M
2023-11-13Seed
Leadership Team
Feng Xuan
Co-Founder & CEO
Recent News
Precedence Research
2025-11-05
Precedence Research
2025-08-13
Company data provided by crunchbase