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SLAS (Society for Laboratory Automation and Screening) · 2 months ago

Senior Research Scientist II / Principal Research Scientist I, Biologics Analytical R&D

North Chicago, IL

Full-time

Onsite

Senior Level

$121K/yr - $230K/yr

4+ years exp

AbbVie is a global biopharmaceutical company focused on innovative medicines and solutions. The role involves developing novel analytical methods for therapeutic proteins and leading cross-functional scientific teams to enhance AbbVie's pipeline of biologic medicines.

AssociationBiotechnologyCommunitiesGovernmentInformation Technology

Growth Opportunities

Responsibilities

Subject matter expert in establishing development of novel analytical methods to characterize peptides, oligonucleotides, ADCs, and novel antibody therapeutics, including HPLC, LC-MS, CD, DLS, SEC-MALS, ELISA/SPR

Contribute to phase-appropriate buildout of analytical methods for extended characterization, product release, stability, comparability, and in-process analytics

Guide and support assay development from development, optimization through validation

Serve as a key scientific and technical representative on cross-functional teams; collaborates and integrates scientific objectives associated with development of new/improved products or technology

Effectively function as an analytical scientist, generating original technical ideas and research or development strategies

Make significant contributions to project team and deliver results in a team-oriented setting and will work across scientific disciplines to drive programs through critical milestones

Generate new scientific proposals and lead those efforts. Anticipate and critically evaluate scientific or regulatory advances or competitive threats and respond with appropriate new strategies

Author, review lab notebook, analytical report, and analytical sections of regulatory filings. Primary author of publications, presentations, regulatory documents and/or primary inventor of patents. Present at leading scientific conferences

May mentor/supervise a team of one or more and guide and evaluate the performance of those individuals; is accountable for the effective performance of the team/individuals

Qualification

HPLCLC-MSBiophysical characterizationAnalytical ChemistryCMC experienceLab automationInterpersonal skillsProblem-solvingTime management

Required

PhD with scientific discipline is preferred (e.g., Analytical Chemistry, Biochemistry, or Biology) with previous laboratory experience

Senior Scientist II: Bachelor's Degree or equivalent education and typically, 12 years of industry experience, master's degree or equivalent education and typically 10 years of industry experience, PhD and typically 4 years of industry experience

Principal Research Scientist I: BS or equivalent education and typically, 14+ years of industry experience; MS or equivalent education with typically 12+ years of industry experience; PhD with typically 6+ years of industry experience in area or scientific area of discipline

Well versed in analytical techniques including but not limited to HPLC, LC-MS, CD, DLS, SEC-MALS, ELISA/SPR

Demonstrated CMC experience with peptides and/or oligonucleotides method developments and optimization

Demonstrate independent problem-solving ability in science and technical proficiency

Strong data and time organization/management skills coupled with strong interpersonal and effective communication skills for facilitating collaborations with a demonstrated ability to lead cross functional process development teams

Preferred

Deep understanding and hands-on experience with biophysical-based and/or mass spectrometry-based higher order structures (HOS) characterizations strongly preferred

Demonstrated experience of lab automation (Lynx, Hamilton, Tecan, etc.) is a strong plus

Practical understanding of fit-for-purpose and stage-appropriate method development, risk assessment and control strategy in Analytical Development setup