Apply on Employer Site

Alaka`ina Foundation Family of Companies · 3 weeks ago

Senior Therapeutics Discovery Technician

Frederick, MD

Full-time

Onsite

Senior Level

5+ years exp

The Alaka`ina Foundation Family of Companies is a fast-growing government service provider seeking a Senior Therapeutics Discovery Technician to support their government customer. The role involves planning, executing, and evaluating high-throughput screening projects and performing microbiological experiments to evaluate therapeutic compounds.

CharityCommunitiesGovernment

No H1B

U.S. Citizen Only

Responsibilities

Assist in the planning, development, execution and evaluation of high-throughput screening projects for the antibacterial, anti-viral, and anti-toxin therapeutic areas and assist in the development of novel assays/methods for various programs. This includes basic cell culture to support these efforts. Shall assist in screening of molecular compound libraries for therapeutic efficacy to support MCM development

Perform both in vitro and in vivo microbiological experiments designed to evaluate therapeutic compounds for antibacterial/antiviral/antitoxin activity. In vitro assays include enzymatic assays, cell-based phenotypic and reporter assays. Minimum Inhibitory Concentration (MIC) and plaque assays. Shall perform standard molecular biology techniques to support development of these assays

Support mouse studies when required. Shall assist with inoculations of animals, collecting specimens for processing, and analysis of those specimens. Analysis may include development and conduct of immunological procedures including Enzyme Linked immunoassay (ELISA), Western blot, and Mesoscale Discovery based assays

Assist in the preparation of technical reports, standard operating procedures, and manuscripts relating to their research efforts. May be expected to present research findings at 1-2 scientific conference per year as needed and CONUS travel may be required. Shall present results in written and oral format publicly and internally as requested

Responsible for assessing and maintaining laboratory supplies in BSL-2, BSL-3 and BSL-4 laboratories. Shall assess supplies and ensure supply orders are coordinated with Division resources. Shall ensure that all assigned laboratory space is orderly and compliant with all regulatory guidance

Perform operations and training in animal manipulations. Support animal studies (mouse, hamsters, guinea pigs, etc.) for funded projects

Provide a Research Technical Report NLT the last day of each month

Communicate to the Lead/PI unexpected experimental data/results and assist in the troubleshooting or root cause analysis. Communicate any laboratory or other work-related issues. Communicate with internal maintenance or external vendors for technical support and troubleshooting

Maintain an orderly laboratory environment in compliance with regulations. Coordinate ordering supplies with division staff. Assist in training new personnel including students and other technicians as needed

Participate in regular laboratory decontamination and cleaning. Main laboratory areas, benches and hoods shall be decontaminated periodically to reduce possible sources of contamination. This task also includes proper disposal of waste and packaging material. Testing of emergency showers, eye washers and drainage systems shall be completed IAW applicable USAMRIID SOPs. Participate in regular instrumentation washes, cleaning and maintenance

Maintain laboratory records documenting sample processing, protocol design and usage, and data management that meet current CGS and Institutional requirements and ensure continuity and collective sharing of resources. Assist in maintaining laboratory equipment, specimens and reagents inventories, as well as keeping an organized, safe and professional work environment

May be required to cross-train and provide laboratory technical support to other areas within the MBD as needed

Present research findings/presentations at monthly lab meetings and attend scientific discussion weekly meetings

Other duties as assigned by Supervisor

Qualification

High-throughput screeningVitro microbiological experimentsMolecular biology techniquesImmunological proceduresLaboratory ManagementAnimal studies supportBSL-2BSL-3BSL-4 experienceEquipment Inventory ManagementTechnical report preparationCommunication skills

Required

Bachelor's degree in biology, Microbiology, Immunology, or similar scientific field of study and five (5) years of relevant laboratory experience

Must have a minimum of two to three (2-3) years' experience planning, developing, executing and evaluating high-throughput screening projects, and developing novel assays/methods

Must have a minimum of two to three (2-3) years' experience within antibacterial, anti-viral, and anti-toxin therapeutic areas

Must have a minimum of two to three (2-3) years' experience performing both in vitro and in vivo microbiological experiments

Must have a minimum of two to three (2-3) years' experience performing standard molecular biology techniques to support development In vitro assays to include enzymatic assays, cell-based phenotypic and reporter assays, Minimum Inhibitory Concentration (MIC) and plaque assays

Must have a minimum of two to three (2-3) years' experience in the development and conduction of immunological procedures including Enzyme Linked immunoassay (ELISA), Western blot, and Mesoscale Discovery based assays

Must have a minimum of two to three (2-3) years' experience performing Equipment Inventory Management

Must have a minimum of two to three (2-3) years' experience performing Laboratory Management within BSL-2, BSL-3, and BSL-4 environments, to include safety functions and chemical inventory

Must have prior experience supporting animal studies (mouse, hamsters, guinea pigs, etc.)

Must be experienced with handling both bacterial and viral pathogens for in vitro and in vivo studies

Must be a U.S. Citizen

BPRP and CS-PRP enrollment required

Must pass NACI background check