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CRB · 1 day ago

Process Engineer III/ IV- Small Molecule/ Oligo/ Peptide

San Diego, CA

Full-time

Hybrid

Senior Level

$120K/yr - $175K/yr

5+ years exp

CRB is a leading provider of sustainable engineering, architecture, construction and consulting solutions to the global life sciences and food and beverage industries. They are seeking a skilled Process Engineer III/ IV with deep expertise in small molecule manufacturing to lead design and execution of process scopes, manage client projects, and mentor junior staff.

BiotechnologyConstructionConsultingWeb Design

Responsibilities

Lead and support client projects focused on small molecule API process development, scale-up, and manufacturing optimization

Conduct site assessments, gap analyses, and provide recommendations for process improvements and compliance

Develop process flow diagrams (PFDs), piping and instrumentation diagrams (P&IDs), and mass/energy balances

Translate client requirements into actionable design scope and document decisions, open issues, and action items

Identify and escalate scope changes or design deviations to project leadership

Collaborate with cross-functional teams including architecture, mechanical, electrical, and construction

Prepare technical reports, proposals, and presentations for internal and client stakeholders

Support capital project planning including feasibility studies, equipment selection, and facility design

Ensure alignment with industry standards including cGMP, FDA, EMA, and ICH guidelines

Participate in advanced project activities such as:

Technical bid tabulations

Vendor package management

Factory acceptance testing

Risk assessments (e.g., HAZOP, HACCP)

3D model reviews and coordination

Sequence of operations and functional specification reviews

Mentor junior engineers and design staff

Lead system design programming and planning with support from senior engineers

Participate in cross-discipline squad checks and drive overall project quality

Qualification

Small molecule process engineeringChemical synthesisCGMP practicesProcess flow diagrams (PFDs)PipingInstrumentation diagrams (P&IDs)Technical report preparationMentoring junior engineersRisk assessmentsCommunication skillsTeam collaborationProject management

Required

Bachelor's or Master's degree in Chemical Engineering or a related discipline (ABET-accredited)

Minimum of 5 years of experience in small molecule process engineering, preferably in a consulting or client-facing role

Strong understanding of chemical synthesis, purification, and formulation processes

Experience in design firm or operating company settings within a related industry

Strong written and verbal communication skills

Intermediate experience with applicable industry and regulatory guidance and building codes

Advanced technical knowledge and experience with small molecule API manufacturing equipment and utility systems, such as chemical reactors, filters, centrifuges, dryers, vacuum pumps, scrubbers, purified water, process compressed gases, and engineered heat transfer fluid systems

Experience designing and implementing engineering controls for containment of highly potent APIs

Experience with cGMP practices within regulated industries (FDA, EMA, JP, etc.)

Preferred

EIT or PE certification

Experience coordinating and managing design within project teams and with external partners

Familiarity with commissioning, startup, qualification, and troubleshooting of process systems

Experience with regulatory environments and validation documentation

Prior experience in engineering consulting or client services

Familiarity with process safety, risk assessments, and HAZOP studies

Demonstrated experience leading a small team of process engineers on complex engineering design projects

Benefits

Comprehensive insurance coverage

Annual incentive programs based on company and individual performance

Complete and competitive benefit package designed to meet individual and family needs

Company

CRB

Glassdoor3.6

CRB is a leading provider of sustainable engineering, architecture, construction and consulting solutions to the global life sciences and food & beverage industries.

Founded in 1984

Basel, Basel-Stadt, CHE

1001-5000 employees