Convergent Research · 2 months ago
E11 Bio - Spatial ‘Omics Scientist
Alameda, CA
Full-time
Onsite
New Grad, Entry, Mid Level
$82K/yr - $123K/yr
0+ years expE11 Bio is a non-profit focused research organization under Convergent Research, dedicated to unlocking whole-brain mammalian connectomics. The Spatial ‘Omics Scientist will co-develop next-generation technology for high-throughput connectomic imaging using molecular barcodes, collaborating with experts to design experiments and analyze data.
BiotechnologyLife ScienceNon Profit
Responsibilities
Develop proteomics methods (e.g. based on oligo-conjugated antibodies) for highly multiplexed detection of antibodies in expansion microscopy using combinatorial imaging
Develop robust signal amplification methods (e.g. rolling circle amplification, hybridization chain reaction) for detection of protein-based cellular barcodes and molecular markers at proteomic scale in swellable hydrogels
Design probe sets and combinatorial imaging experiments (e.g., in situ sequencing, MERFISH) compatible with expansion microscopy to detect cell barcodes in brain tissue
Integrate and apply automatic liquid handling and automatic fluorescence imaging methods in a robust and reproducible pipeline
Process and analyze multiplexed image volumes, including stitching and registration across imaging cycles, and feature detection, decoding and classification
Work closely with experimental and computational scientists at E11 and through external partnerships to collaboratively design experiments, analyze experimental data, and interpret results
Maintain excellent laboratory notebook practices, prepare reports and manuscripts, and present results internally and externally, and source new techniques from the scientific community
Qualification
Required
PhD in biology (e.g. biophysics, bioengineering, molecular biology) or a related field in science and/or engineering, or equivalent working experience and track record
Scientist I: 0-3 years of experience post-PhD, or equivalent industry track record; Scientist II: 3-6 years of experience post-PhD, or equivalent industry track record
Experience with 3D spatial transcriptomics (e.g. in situ sequencing and/or multiplexed hybridization) and/or spatial proteomics (e.g. multiplexed DNA-barcoded antibodies)
Extensive experience with spatial methods/protocol development, with emphasis on DNA-based readout such as HCR or RCA
Experience with fluorescence microscope modalities, including spinning-disc confocal microscopy
Experience with molecular biology laboratory techniques, e.g. cell and tissue culture, molecular cloning, quantitative PCR, immunohistochemistry, etc
Preferred
Experience with expansion microscopy and/or hydrogel embedding for expansion microscopy
Experience with fluidics for multiplexing, microfluidics, and automation
Experience with computational image analysis methods for combinatorial imaging
Excellent communication skills, record keeping ability, and attention to detail
Excellent interpersonal and collaboration skills
Strong record of publications in peer reviewed scientific journals
Benefits
Excellent medical, dental, and vision insurance through a PPO plan; parental leave.
Generous time off + paid holidays.
Ample healthy and energizing food including daily lunches.
Wellness allowance for fitness and wellness activities.
Health and wellness stipend
Matched 401K contributions
Corporate holidays
Flexible employee vacation
Company
Convergent Research
Convergent Research is a focused research organization for conducting non-profit science projects and research.
51-200 employees
H1B Sponsorship
Convergent Research has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2023 (11)
2022 (5)
Funding
Current Stage
Growth StageTotal Funding
$1.97MKey Investors
Alfred P. Sloan Foundation
2023-01-01Grant· $1.97M
Leadership Team
Adam Marblestone
Chief Executive Officer
Anastasia Gamick
Cofounder & Chief Operating Officer
Recent News
Genetic Engineering News
2025-05-17
sloan.org
2023-10-26
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