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Flagship Pioneering · 3 months ago

Principal Scientist, Computational Protein Design

Cambridge, MA USA

Full-time

Onsite

Senior Level, Lead/Staff

5+ years exp

Flagship Pioneering is a bioplatform innovation company dedicated to transforming human health through cutting-edge scientific ventures. They are seeking a Principal Scientist in Computational Protein Design to lead the technical development of AI-based antibody design, collaborating with Pioneering Medicines to advance new therapeutic solutions.

FinanceFinancial ServicesVenture Capital

H1B Sponsor Likely

Responsibilities

Design and optimize antibodies using AI-based and structure-based approaches for binding and functionality

Create and apply computational methods for assessing and optimizing developability (stability, solubility, manufacturability, immunogenicity, polyreactivity, polyspecificity)

Improve AI models with experimentally generated data

Stay at the forefront of AI and computational tools in antibody engineering

Provide scientific leadership and mentor team members

Qualification

Computational Protein DesignAI-based Antibody DesignAntibody OptimizationDeep Learning ArchitecturesAntibody Developability AnalysisScientific LeadershipTeam Mentorship

Required

PhD in Biochemistry, Structural Biology, Biophysics, Protein Engineering, Computational Biology, Computer Science, or related field with 5+ years of relevant industry experience

Proven experience in the end-to-end design and optimization of antibodies for binding, functionality, and developability

Strong track record in utilizing AI and computational methods for antibody engineering, including but not limited to AI-based co-folding models and design models, and related structure-based design tools

Experience analyzing and interpreting antibody developability data

Experience leading projects in antibody discovery or biologics development

Preferred

Expertise in a breadth of antibody modalities, including mAbs, bispecifics or multispecifics, antibody-drug conjugates (ADCs), and antibody fragments

Experience developing and training novel AI and machine learning models for protein engineering utilizing deep learning architectures

Company

Flagship Pioneering

Glassdoor3.3

Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.

Founded in 2000

Cambridge, Massachusetts, USA

501-1000 employees

http://flagshippioneering.com

H1B Sponsorship

Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

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Trends of Total Sponsorships

2025 (8)

2024 (4)

2023 (4)

2022 (4)

2021 (1)